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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PDK3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5165
Official gene symbolPDK3
Full namepyruvate dehydrogenase kinase, isozyme 3
Aliases,-,
Gene summaryThe pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: X   Locus: Xp22.11
Gene position24483344 - 24568583  Map Viewer
Gene orientationplus
Gene size85240 bp
Gene sequence