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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ENPP2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5168
Official gene symbolENPP2
Full nameectonucleotide pyrophosphatase/phosphodiesterase 2
Aliases,ATX,ATX-X,AUTOTAXIN,FLJ26803,LysoPLD,NPP2,PD-IALPHA,PDNP2,
Gene summaryThe protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
LocationChromosome: 8   Locus: 8q24.1
Gene position120651106 - 120569319  Map Viewer
Gene orientationminus
Gene size81788 bp
Gene sequence
OMIM ID601060