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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GHRL (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID51738
Official gene symbolGHRL
Full nameghrelin/obestatin prepropeptide
Aliases,MTLRP,
Gene summaryThis gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq]
LocationChromosome: 3   Locus: 3p26-p25
Gene position10334631 - 10327434  Map Viewer
Gene orientationminus
Gene size7198 bp
Gene sequence
OMIM ID605353