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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PEG3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5178
Official gene symbolPEG3
Full namepaternally expressed 3
Aliases,DKFZp781A095,KIAA0287,PW1,ZSCAN24,
Gene summaryIn human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]
LocationChromosome: 19   Locus: 19q13.4
Gene position57352094 - 57321445  Map Viewer
Gene orientationminus
Gene size30650 bp
Gene sequence
OMIM ID601483