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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CFP (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5199 Official gene symbol CFP Full name complement factor properdin Aliases ,BFD,PFC,PFD,PROPERDIN, Gene summary This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified. Location Chromosome: X   Locus: Xp11.3-p11.23 Gene position 47489704 - 47483612  Map Viewer Gene orientation minus Gene size 6093 bp Gene sequence >CFP:complement(10335356..10341448):Length=6093 GAGCACCGCACACTCACTTCACCCTGGTTCAACACCCCCACGAGGTTGACCCCGTCATTA TGTTAGAGATTATGCATTTTCCACATAGGGAAACTGAGGCTCAGGGGTGTTAAGTGACTC ACCCAAGGTCACACGGCTAGGAAGTTGCTGCACGCTCCTATGCTCCATTTCCTCTGGGTG AGAATTTGTCCTAGGAGCTTCTATTGAACACTGTGAGGTTGCTGGGAGGAGCGCGAGGTG CTGGGGATATAGTAACAAACAGAACAAGACCAAGAGTAAGACAGGAAATGGGGAGGGGAG AGTAGAGAAGGAGGCAGAGGGGACAGGGTGGGGTCAAAGCAGGATGCCCTCCCAGTTCCT CCTGCCTCTAGGTTCCTCTTTCCCTGCTGATTCCAGGAGCCTATCAACCCAGATAAAGCG GGACCTCCTCTCTGGTAGAGGTGCAGGGGGCAGTACTCAACATGATCACAGAGGGAGCGC AGGCCCCTCGATTGTTGCTGCCGCCGCTGCTCCTGCTGCTCACCCTGCCAGCCACAGGTG AGGGGGTGAGGGCCCAGCTGGCCCCAGGGGTGTCCAGGCCCACCACATCCCTGACCGAGC CCCACCCACCCATCCCCTGGCCCTGTTACAGGCTCAGACCCCGTGCTCTGCTTCACCCAG TATGAAGAATCCTCCGGCAAGTGCAAGGGCCTCCTGGGGGGTGGTGTCAGCGTGGAAGAC TGCTGTCTCAACACTGCCTTTGCCTACCAGAAACGTAGTGGTGGGCTCTGTCAGCCTTGC AGGTTAGGGGGAGCCTGGGGTGGGGGATGGGGGGGAGGGAAGGACTGTCTGTGGGGGTCA CCCAAAACTGGGCACTTTCTTTCTCTGGGACTTCCAAGGGTGGCCCTGAGGCCCTGATCG TGACCATACCTCAGGGTTTCTCAACCTTGTTACTATTGACATTTGGGGCTGGAAATTCTT GGCTGGGGGAGGGGATTGCTTACCTGTGTATTGTGGGATGTTTTGTAACACCCCTAGCCT TCCACTAGATGCCAGTAGCAATTCTCCCCACCAGCTGTGACAACCAAACATGTCAGCAGA CATTGCCAAATGTCCCCTGGGGGTCAAAATCACCCCTGATTGAGAACCACTGACATAGCT CACACATATTGAGCACCTCCTGCACACTGGAAGCATTGCAGGTGGGGTGCAGCTTGGTAT TTCCCTAATTTTGATGACAGCTCATGTTTATTGAGTGCTTACTGTATATGGACACACTGT GGGGGCGGGAAAGTTTGGGGAATTCAAAGGGCAGCTCTAGGCCCCTAATTATGATGACAC TTCACATTCATTGAGCACTCCCTGTATACCAGCTGCATGGCAGGGTTGGGAGATGAGCTT GAGGATTTCTGAGGGTAGCTCTAGTCTCCTGATCATGATTTCCAGCTTGCATGGATTGAG CCCTTACCGTATGCCAGACCTGTTTTCTACTTGTTTACTATATATCCCAGATACACCGTG GGCATGGGGAGCTTGGGGATTTTTGAGGGCAGCTCTGGGCCCCAAGTCATGTCAACAGTT CATCACATCTATTTGGCATGAACAGCATACCTAGGGCTATGCAGTGGGTTGGGGATAGAT CTGGGGTTATTTCTGAGGAGGCCTCTGAGGTCATAGGGATGATGGCTCAGGTTTATTAAG CACTTTCTATTTACCTACTACCGTGTAGTGTGGTGATCTGGTGGGTTTCTGACAGCAGCC CTTGGTTTCTAGTCCTTACCTTTGCTTACTGCGGACCTGGTGTTGGCCATGCAGCCTTCC AATGGTAACTCCAGATGCCTGATTGTGAAGGTAAATGACATTATCAAGCACTTATTGTAT ATCCACTGCTTCCCATCAGTATCCCAATATCCCTAAAAGGTAAGGACTTATCAATCCATC GCACACGCACTTGCCTAGCAACCCTTCGTGTCTGCCCACACTCTGGAGTCCCACATGCCA TTCTTGTTAGCTCATGCCAGGATGGGATGTGTGTGCTCTTCTCCACAGGTCCCCACGATG GTCCCTGTGGTCCACATGGGCCCCCTGTTCGGTGACGTGCTCTGAGGGCTCCCAGCTGCG GTACCGGCGCTGTGTGGGCTGGAATGGGCAGTGCTCTGGAAAGGTGGCACCTGGGACCCT GGAGTGGCAGCTCCAGGCCTGTGAGGACCAGCAGTGCTGTCCTGGTGAGGAGGATGAGCA AGGCGGGCAAGCACTCCCTGTCACCCAGCACTGGTGGGAACGATCGGTACAGAGGTCCTC AGAGTGGGCCCGTCCCCAGTGTTTGTAAGGACCTAAGGAGGAGAGTGGTGGGAGGTGAGG TCAGAGAGGTGAGGAGGGTCCATTGCCTGGGGGCCACAGAGAGGACGTTGGCTTTTCATC TGAGTAATTTGGACTGTGGGCAGAGGAGGAACGTGATCTGACTGGGGTTGGGAGGAGAAC AGACTGTGCACGGTGAGGGTGAGAGGGGAAGCGGAGGCACCCATGTGAAGGTTGCTGCGG CAGGCCCGGTGAGCGGGGATGGTGGGCCCAGAATGGTGGCAGAGGATATAAGGACAGGAT TAGCTCATGTGGGGCACTCAAGGAAGCAAAGAGCCCTGAATGACACCCCACCTCCATCCC ATTACCCTCTCTTCTCTCCCACAGAGATGGGCGGCTGGTCTGGCTGGGGGCCCTGGGAGC CTTGCTCTGTCACCTGCTCCAAAGGGACCCGGACCCGCAGGCGAGCCTGTAATCACCCTG CTCCCAAGTGTGGGGGCCACTGCCCAGGACAGGCACAGGAATCAGAGGCCTGTGACACCC AGCAGGTCTGCCCCAGTGAGTGAGGGAAGCCACAGGATGCTGATGGGTGCACCCAGCGTG GGTCTGCGGGGTTACAGCAGGGAACTGCCAGGCTGAGAGGACTTTAGCATGCATGACCAC ACCTGCATCCCTCCACCTCCCACCCCACCACAGCACACGGGGCCTGGGCCACCTGGGGCC CCTGGACCCCCTGCTCAGCCTCCTGCCACGGTGGACCCCACGAACCTAAGGAGACACGAA GCCGCAAGTGTTCTGCACCTGAGCCCTCCCAGAAACCTCCTGGGAAGCCCTGCCCGGGGC TAGCCTACGAGCAGCGGAGGTGCACCGGCCTGCCACCCTGCCCAGGTACACCAGGATGAG GCTGCTGATGTTGCTGGTGGGGCTCTTGATTGAGGGCAGAGATGCTCTGCCATTTCTAGA GTTCCTAGGCCATGTGACCATGCAGCCCTTCATTTGGGGACAGTCTGCTTCAAGGGTCTA GGGGCTGAGAGGAAGGATTGAGGAGGCCTTTCTCCTCACTCCCTTTCCTCCTCCAACAGT GGCTGGGGGCTGGGGGCCTTGGGGCCCTGTGAGCCCCTGCCCTGTGACCTGTGGCCTGGG CCAGACCATGGAACAACGGACGTGCAATCACCCTGTGCCCCAGCATGGGGGCCCCTTCTG TGCTGGCGATGCCACCCGGACCCACATCTGCAACACAGCTGTGCCCTGCCCTGGTCAGCA TCTCAGGGTTCACGATTTGCATGCCTAAGTCCCCCTTGCCCTTCTCTGCTGCCCAGCTCC TGCTGCTGAGGCCTTGTTCCTGTCTCTGATTCCTCCTTTCCTGGCCCTGATACCTTGTTT CCACCCCTGGTCCCCCATTCACACATCTGATCACCTCTACTCCCTCCTACCGCCCTCATT CCTTCCTCTGAACCCCCTTGCTGATTCCCTGCTTTGGTCCAATCCCCTGTTGCCCTGTCT CTGCAGTGGATGGGGAGTGGGACTCGTGGGGGGAGTGGAGCCCCTGTATCCGACGGAACA TGAAGTCCATCAGCTGTCAAGAAATCCCGGGCCAGCAGTCACGCGGGAGGACCTGCAGGG GCCGCAAGTTTGACGGACATCGATGTGCCGGGCAACAGCAGGATATCCGGCACTGCTACA GCATCCAGCACTGCCCCTGTGAGTGTCCCACAGACTGTGCTCTGAGGGTGGGGTGGCCCA TGCAGGATAAGGGGTTTCCAACTCTCTGCTGTGGACCTCACGTCTCTGCAGCCTCCCTCT CACTTTCCCACCAAGACCTCCAGTTCTGACTCTGTGACCCCTACCCCTCATTGCAGTGAA AGGATCATGGTCAGAGTGGAGTACCTGGGGGCTGTGCATGCCCCCCTGTGGACCTAATCC TACCCGTGCCCGCCAGCGCCTCTGCACACCCTTGCTCCCCAAGTACCCGTGAGTGAGAGG GCAAAGTATGCCTGGGAGGGGGTCATTATATTACAGGCGGGAGAGTCGGCTACCCCAGGA AACCAGGGTTTCCACTGCTGAATCTAAGGTATCTGCCTTGCCGAGTGCCACCTCCCAGCT GCAGGAAGTGGGGAGAAACTAAGAAGATGAGAAAGAAGTTCTTGGAGGATAATTCGTAGC CTCTGTGCCCCTCAGTCACCTGTTCAGTCACTCATCCACTTAGTCCTTCATGTGTCATTG ACTCCGACCTTCAGTTACCCATGCTTTTAGCTGCCATCACTCAGGCCTCCATTCACTGCC TGCCTCCCACAGTCACTCATGCCTCCATCCACTTTGTCAGCATCTCACTGAGCCAAGGCA CTCCAAGGCTTTTTCAGCAACAGTTGCAGATACACACAGCCCAGATCCTGTGGATCCTCC AAGGGACCCAGCTGAGCAAGCCCCTGACAGGAGGCATATGAGGAACAGCTGGTGCATGCA ACAGGTGCTGCCACCTCAACCTAGGTCCAGGAAGCTGACTGGGCCTCCCAGGGCAGGTAG GGGTTGGGAAAGGCATTCCTGGCATCAAGACTGTGAACGGAGCCTTGGAGCTAGGTGATT AGCCGCTATAAGTGTTTCCAGGTGCCAGAGGGGCCCAGGTGTTAGAGAGGGTTAAAATGT TCATCCCTTTTCTTCCTTCCACATACATCAAGCTACTAGATTAAGTGAACTATTCCCAGC TCGTGGAAGGGCTGCCATCTGGGAAGGGATCTCCCGGCTGAGGGGGTTAGAGTGGGGCCT GAAGATTAGAGGTGTTGAATGGAGGCACAAAGGACTTGAGTGAGCGAGAGACTGAGTGGA GGAAGAAGCAATTGAGAGAACTGGGATGGGAGTGAATGGAGGGCTTTCCTAGTGGGACAA ATAACCCAGGTAAAGACCTTTCTGGACAGGGACTGAGCTTGAATAAAGTGGAGGAGACAG AGAGAGAGATTGGCTTGGGGCAGGGATTTGGGCCCAACAATAAGGCCTTGAATGTCAGGA CAAGGCATTGGGTTTTTTCCTGGAGGCAGTGGAAAGAGATATAAAGGGTATATATTTCGG AGGTAAAAGAAAGTAGCTCATGCCAACAAGTAACATTCACCAGCATTTATTGAGCACTTG CTGTGTGCCAGGCACTGCTCTGAGCACTTTACCTGAATTAACTCATTTATCCTCATTCAA CCCCGTGAGGTGAGTATTAATATTACTATTCCTACCATTCTCATTTTGCAGATGAGGGAA ACCGAGGCACAGAGAAGCTAAAGAAATTGCCCAATATCCTATAGCTAAAAAGTAGTGTTG GGAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCAACACTTTGGGAGGCTGAGGCA GGAGCATCACTTGAGCCCAGGAGATTGAGGCTGCAGTGAGCTATGATTGTGCCACTGCAC TGCAGCCTGGGCAACAGAGTGAGACCCTGCCTCAAAAAAAAAAAAGGAAAAAAAAAAAAA AAAAAAGTAGCCCTCGGCATATAGCAGGCACTCAATAAGAATTGAATGCATTCTTGCCTT CCCTGAGATTCTCCCTTCCGTTCCTCCCCACCCCTAATGCCTCAGGCCCACCGTTTCCAT GGTCGAAGGTCAGGGCGAGAAGAACGTGACCTTCTGGGGGAGACCGCTGCCACGGTGTGA GGAGCTACAAGGGCAGAAGCTGGTGGTGGAGGAGAAACGACCATGTCTACACGTGCCTGC TTGCAAAGACCCTGAGGAAGAGGAACTCTAACACTTCTCTCCTCCACTCTGAGCCCCCTG ACCTTCCAAACCTCAATAAACTAGCCTCTTCGA OMIM ID 300383