Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PFKFB2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5208
Official gene symbolPFKFB2
Full name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Aliases,DKFZp781D2217,MGC138308,MGC138310,PFK-2/FBPase-2,
Gene summaryThe protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q31
Gene position207226620 - 207254368  Map Viewer
Gene orientationplus
Gene size27749 bp
Gene sequence
OMIM ID171835