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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ABCB1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5243
Official gene symbolABCB1
Full nameATP-binding cassette, sub-family B (MDR/TAP), member 1
Aliases,ABC20,CD243,CLCS,GP170,MDR1,MGC163296,P-GP,PGY1,
Gene summaryThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q21.12
Gene position87342564 - 87132948  Map Viewer
Gene orientationminus
Gene size209617 bp
Gene sequence
OMIM ID171050