Entrez gene ID | | 526 |
Official gene symbol | | ATP6V1B2 |
Full name | | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 |
Aliases | | ,ATP6B1B2,ATP6B2,HO57,VATB,VPP3,Vma2, |
Gene summary | | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq] |
Location | | Chromosome: 8 Locus: 8p22-p21 |
Gene position | | 20054704 - 20079207 Map Viewer |
Gene orientation | | plus |
Gene size | | 24504 bp |
Gene sequence |
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OMIM ID | | 606939 |
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