Entrez gene ID | | 527 |
Official gene symbol | | ATP6V0C |
Full name | | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c |
Aliases | | ,ATP6C,ATP6L,ATPL,VATL,VPPC,Vma3, |
Gene summary | | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16p13.3 |
Gene position | | 2563953 - 2570219 Map Viewer |
Gene orientation | | plus |
Gene size | | 6267 bp |
Gene sequence |
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OMIM ID | | 108745 |
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