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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SERPINB8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5271
Official gene symbolSERPINB8
Full nameserpin peptidase inhibitor, clade B (ovalbumin), member 8
Aliases,CAP2,PI8,
Gene summaryThe superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM]
LocationChromosome: 18   Locus: 18q21.3
Gene position61637263 - 61656608  Map Viewer
Gene orientationplus
Gene size19346 bp
Gene sequence
OMIM ID601697