Entrez gene ID | | 5273 |
Official gene symbol | | SERPINB10 |
Full name | | serpin peptidase inhibitor, clade B (ovalbumin), member 10 |
Aliases | | ,PI10,bomapin, |
Gene summary | | The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM] |
Location | | Chromosome: 18 Locus: 18q21.3 |
Gene position | | 61582745 - 61602476 Map Viewer |
Gene orientation | | plus |
Gene size | | 19732 bp |
Gene sequence |
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OMIM ID | | 602058 |
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