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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PIK3C2A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5286
Official gene symbolPIK3C2A
Full namephosphoinositide-3-kinase, class 2, alpha polypeptide
Aliases,CPK,DKFZp686L193,MGC142218,PI3-K-C2(ALPHA),PI3-K-C2A,
Gene summaryThe protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p15.5-p14
Gene position17191354 - 17108122  Map Viewer
Gene orientationminus
Gene size83233 bp
Gene sequence
OMIM ID603601