Entrez gene ID | | 5287 |
Official gene symbol | | PIK3C2B |
Full name | | phosphoinositide-3-kinase, class 2, beta polypeptide |
Aliases | | ,C2-PI3K,DKFZp686G16234, |
Gene summary | | The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q32 |
Gene position | | 204459474 - 204391758 Map Viewer |
Gene orientation | | minus |
Gene size | | 67717 bp |
Gene sequence |
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OMIM ID | | 602838 |
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