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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PIK3C2B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5287
Official gene symbolPIK3C2B
Full namephosphoinositide-3-kinase, class 2, beta polypeptide
Aliases,C2-PI3K,DKFZp686G16234,
Gene summaryThe protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q32
Gene position204459474 - 204391758  Map Viewer
Gene orientationminus
Gene size67717 bp
Gene sequence
OMIM ID602838