Entrez gene ID | | 5315 |
Official gene symbol | | PKM |
Full name | | pyruvate kinase, muscle |
Aliases | | ,CTHBP,HEL-S-30,OIP3,PK3,PKM2,TCB,THBP1, |
Gene summary | | This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q22 |
Gene position | | 72523684 - 72491370 Map Viewer |
Gene orientation | | minus |
Gene size | | 32315 bp |
Gene sequence |
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OMIM ID | | 179050 |
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