Entrez gene ID | | 53335 |
Official gene symbol | | BCL11A |
Full name | | B-cell CLL/lymphoma 11A (zinc finger protein) |
Aliases | | ,BCL11A-L,BCL11A-S,BCL11A-XL,CTIP1,EVI9,FLJ10173,FLJ34997,HBFQTL5,KIAA1809,ZNF856, |
Gene summary | | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2p16.1 |
Gene position | | 60780633 - 60678302 Map Viewer |
Gene orientation | | minus |
Gene size | | 102332 bp |
Gene sequence |
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OMIM ID | | 606557 |
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