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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PLOD1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5351
Official gene symbolPLOD1
Full nameprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
Aliases,FLJ42041,LH,LH1,LLH,PLOD,
Gene summaryLysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.22
Gene position11994746 - 12035594  Map Viewer
Gene orientationplus
Gene size40849 bp
Gene sequence
OMIM ID153454