| Entrez gene ID | | 5358 |
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| Official gene symbol | | PLS3 |
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| Full name | | plastin 3 |
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| Aliases | | ,T-plastin, |
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| Gene summary | | Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants. |
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| Location | | Chromosome: X Locus: Xq23 |
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| Gene position | | 114795177 - 114885181 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 90005 bp |
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| Gene sequence |
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| OMIM ID | | 300131 |
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