Entrez gene ID | | 53615 |
Official gene symbol | | MBD3 |
Full name | | methyl-CpG binding domain protein 3 |
Aliases | | ,-, |
Gene summary | | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19p13.3 |
Gene position | | 1592652 - 1576678 Map Viewer |
Gene orientation | | minus |
Gene size | | 15975 bp |
Gene sequence |
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