Entrez gene ID | | 53905 |
Official gene symbol | | DUOX1 |
Full name | | dual oxidase 1 |
Aliases | | ,LNOX1,MGC138840,MGC138841,NOXEF1,THOX1, |
Gene summary | | The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q15.3 |
Gene position | | 45422192 - 45457774 Map Viewer |
Gene orientation | | plus |
Gene size | | 35583 bp |
Gene sequence |
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OMIM ID | | 606758 |
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