Entrez gene ID | | 5395 |
Official gene symbol | | PMS2 |
Full name | | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) |
Aliases | | ,HNPCC4,PMS2CL,PMSL2, |
Gene summary | | This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7p22.2 |
Gene position | | 6048737 - 6012870 Map Viewer |
Gene orientation | | minus |
Gene size | | 35868 bp |
Gene sequence |
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OMIM ID | | 600259 |
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