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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for WNT4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID54361
Official gene symbolWNT4
Full namewingless-type MMTV integration site family, member 4
Aliases,SERKAL,WNT-4,
Gene summaryThe WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.23-p35.1
Gene position22469519 - 22443798  Map Viewer
Gene orientationminus
Gene size25722 bp
Gene sequence
OMIM ID603490