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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FBXW5 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 54461 Official gene symbol FBXW5 Full name F-box and WD repeat domain containing 5 Aliases ,DKFZp434B205,Fbw5,MGC20962,RP11-229P13.10, Gene summary This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq] Location Chromosome: 9   Locus: 9q34.3 Gene position 139839173 - 139834887  Map Viewer Gene orientation minus Gene size 4287 bp Gene sequence >FBXW5:complement(617890..622176):Length=4287 CGGGGCTCGTGGCGTCGGGCCTGGCGGGCTCCCCGTTGGGCGGGGGCGGCGGTCCGAGCG GCTGCGGCAGCGGAAGCGGGTCCGGGTCGCGCAGGGCGGGGGCGGCGCAGCGGGCGGAGG CGGCCGTGGTGAGTGCGCCTGCGGCCCTCGGGGGTCCCGCCTTGTCGTCCCCGCCCGCCT TGGGCGAGTGCAGGAGCCCCGAGGCCGCCCGTGCGCTCGTCCCCGCCGTCCGCCCCGAGC CCGCCGGGCAGAGCTGCTCCAGGGCCGCAGGGCGGAGGCCACTGCCTGGCCGCCCCGAGC TTCCTCTCGGCGGAAGCCCGTCCCCGGACGGCGCCTGGTGTCCCCGTGCCTCGCGTGCGG CGGTCCGGGCCCTGGCGGGCTGAGGGGCGCCCGCTGCCGGCCGCAGGAGGCCGGGGGATG ACGCGGCGGAGAGGGGCCGGCCCGGCCCGCCCGGAGCTGCCGGGTCCTTGGTTGGGCGGC GGTACCCGGGCGTCCCCTGCAGACACGCAGCCCCGTGGAACTCCCGGCGGGACGGTTGGG GCTGGAGGAACAGGACGCCCGCTCTCGGCCTCCCTTCCCGGGCCTGGGCTGAGGGCAGCC GTTGGTGGGTTTCAGGGCCGCCTGGGCAGAATGTCACGATGGACGAGGGCGGCACGCCCC TGCTCCCCGACAGCCTGGTCTACCAGATCTTCCTGAGCCTGGGCCCGGCCGACGTGCTGG CCGCCGGGCTGGTGTGCCGCCAATGGCAGGCCGTGTCGCGGGACGAGTTCCTGTGGAGGG AGCAGTTCTACCGCTACTACCAGGTGGCCCGCGACGTGCCCCGACACCCAGGTCAGTGGC GTGTGGGGCCCCTACCCACGTTCTGCAGCCAGGGCCCCGGGCCCCTGCGCTTGGGGGTCA GCCTGGCTGGGGGCCCGCCCCGCGGCCCCGCGTGTCCATGCTCACCCCCCCACACCCTGA TAGAGGCCTGTCAGGACACAGCGCAGGCGCCCCTCAGAGCTTGGAGGCCAGAGGGTTCAT TGGGTCACTTGGGGGGTGGGGGGTACAGGGGTCTCTGTGAGCTACAGGGTTGAATCCCCC AGCCGAGGCCTATGCCATGACTAGTGGGTTCCAGGGGCACCACGGGGCCTGCCAGGACTG CTGGGGCCACACTCGGCTCATGGCCGTGACTGCGAGGAAGGCCCGGGCCCAGGACTGACA ACTGCCCACCCGCAGCGGCCATGTCCTGGTACGAGGAGTTCCAGCGGCTGTATGACACGG TGCCCTGCGTGGAGGTGCAGACGCTGCGGGAACACACAGACCAGGTCCTGCACCTCAGCT TCTCCCATTCCGGGTACCAGTTCGCGTCCTGCTCCAAGGACTGCACTGTGAAGGTGAGGA CGGCCAGGTGTCCTGCACACCCCACCCAGCTCTGCCGCAGCACGGAGGTCCCAGGACCCA GGCGTTCCAACCAGGTGGTGGTGGGGGGGGGGGTGGGTCAGGCCAGAGGTGACAGCAGCC TCCCTGCATCCAGCGGAGGGACCACAGAGGATCAGGAGCGGTGCAGGGTGGCCCTGAGTG CTGAGGAGAGGGTCCCACACACAGCCGCCTGCTTCAGGGGCAGGCTCCTCCGCTCTATAC CAATGCCCCCCGAGTGGATGACAGTGGCTGGAAGGGGTCCCTGCTCCCTGGTGGCCTCTG AGTAGGGCTGGCAGAGCTGGGGCCTCATGGCTGTGTAGTAGCAGGCCCCCGCCCCGCGAC CTGGCCAGGCGATCACTACAGCCGCCCCTGCCGAACAGATCTGGAGCAACGACCTGACCA TCTCGCTGCTGCACAGCGCGGACATGCGGCCCTACAACTGGAGCTACACCCAGTTCTCCC AGTTCAACAAGGACGACTCGCTACTGCTGGCCTCGGGGGTGTTCCTGGGGCCGCACAACT CCTCATCCGGCGAGATTGCTGTCATCAGCCTAGGTGAGCACGGGCGGCGGGTTGACCCTG CCCCCGCCCCACGCCGACAGCCTGTCCAGCCCCGGCCTCCCCACAGACTCCTTCGCGCTG CTGTCCCGCGTGCGGAACAAGCCCTATGACGTGTTTGGCTGTTGGCTCACCGAGACCAGC CTCATCTCGGGGAACCTGCACCGCATCGGAGATATCACCTCCTGCTCGGTGCTGTGGCTC AACAATGCCTTCCAGGTGCGTGCGGGGCTAGGGGCGGGGCTGCCCTCCTGGGGCCTGGCG CCCGGCGCCCACCTGGCACGTGCCCCCGCCCCCAGGATGTGGAGTCAGAGAACGTCAACG TGGTGAAGCGGCTGTTCAAGATCCAGAACCTCAATGCCAGCACCGTCCGCACGGTGATGG TGGCCGACTGCAGCCGCTTCGACAGCCCTGACCTGCTGCTGGAAGCCGGTGACCCGGCCA CGTCCCCCTGCCGCATCTTTGACCTGGGCAGCGACAACGAGGAGGTGGTGGCTGGCCCGG CCCCCGCCCACGCCAAGGAGGGCTTGCGGCACTTTCTGGACCGCGTGCTGGAGGGGCGGG CGCAGCCACAGCTGTCGGAGCGCATGCTAGAGACCAAGGTGGCCGAGCTGCTGGCCCAGG GCCACACCAAGCCACCCGAGCGCAGTGCCACAGGCGCCAAGAGCAAGTACCTCATCTTCA CCACTGGCTGCCTCACCTACTCCCCACACCAGATCGGTACACCCCTGCCGCCATGCTGCC CGCCTCGGTCCTAGGAGCTTGGGGGAGGCCGGGCAGGGGTCCTGAGGGGCAGACAGCAAG CAAGTCCACAGGCAAAGCTGGGATCGTTCACTCGCCCCTGGGGTCACAAGCCCAGACCTG GGGCCTGTGGGATGAGCAGTGAAAACAAACGCAGGCAGGGCCGCTGGCCAGCAAGCAACC GACGGGCCTGATTCAGGTCTGGGGCCCCCGGAGCAGGCAGTGCCCACGGACCTCTGTGGT GCTCACAGCCCCAGAGACACCACTGAGGTAGGAAGCTGCCCTGGAGTGATGTCCTTGGGG CATTGGACAGGGACCCTCACCGTAGCCCTCCCTGCAGGCATCAAGCAGATCCTGCCACAC CAGATGACCACGGCAGGGCCCGTGCTGGGTGAGGGCCGGGGCTCCGATGCCTTCTTCGAC GCGCTGGACCACGTCATAGACATACACGGACACATCATCGGCATGGGCCTGTCGCCCGAC AACAGGTGGGCCTCTTGCCAGTGTCCCAGGCGGGGTGCCCGCAGGCGGCCCACACCTAGC ACAGTGCCCCTCGCCCAGGTACCTGTACGTGAACAGCCGCGCCTGGCCCAACGGTGCGGT GGTGGCCGACCCCATGCAGCCGCCACCAATCGCGGAGGAGATTGACCTGCTGGTGTTCGA CCTCAAGACCATGCGGGAGGTGAGGCGGGCTCTGCGTGCGCACCGCGCCTACACGCCCAA CGACGAGTGCTTCTTCATCTTCCTGGACGTCAGCAGGGACTTCGTGGCCAGGTGCAGGGC GCGGCGTGGTGCAGGGCGGGTGTGGGCAGCAGCGGGCGGGCGGCCGGCTCACCCAGGCGC TGTTCTGCAGCGGGGCGGAGGACCGGCACGGCTACATCTGGGACCGCCACTACAACATCT GTCTGGCCAGGCTGCGGCACGAGGATGTGGTCAACTCAGTGGTCTTCAGTCCCCAGGAGC AGGAGCTGCTGCTCACGGCCAGCGACGACGCCACCATCAAAGCCTGGCGCTCCCCACGCA CCATGCGCGTCCTCCAGGCACCTCGCCCACGGCCTCGCACCTTCTTCTCCTGGCTTGCCA GCCAGAGGCGCTGAGGTGTGCTGGGTGCACTGGAGCCACCGGGACCCCTTGAGGACATCG CCAGGCTCTGTGGCTTTTTCCCGAGCGGGAGAGGTGGAGATGCTTATAGCAGTTACGCCT TAGGAAGGGGACAACCAGGCCCCGCCACACGCTCACACACAAACCTGCTCACGCAGCTGT GATGCTTGGCACGGGGTGGCCAGTGCAGATGGAGCCCAAGGCCCCCTCGGCCTCCTGGGC AACTTGGGGTACACAGGATACTGGGGGTGCCGCTCCTCACTCAACCCCAGGCTAGGGGTA CACCTGACCCAGCTGGCCTCGGCCCGGGGCACCTTCGGCTGGTCCTGTGGGGCCCTGGAC GGTGGCCCAGTGGTGGCAGGGGCTGCTCCTGGCTGTGGTTGTGCGCCCGGGGCTTGGGAG CGGCCGGTCACGCTGCTGTGGGCCCGAGTGTGTTGCATGTCCACGCACCACCCGTTCAGG GCCCTGAATAAACAGTTGGCAACAGCA OMIM ID 609072