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Gene information for UGT1A8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID54576
Official gene symbolUGT1A8
Full nameUDP glucuronosyltransferase 1 family, polypeptide A8
Aliases,UDPGT,UDPGT 1-8,UGT1A8S,UGT1H,
Gene summaryThis gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q37
Gene position234526291 - 234681945  Map Viewer
Gene orientationplus
Gene size155655 bp
Gene sequence
OMIM ID606433