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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PCSK4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 54760 Official gene symbol PCSK4 Full name proprotein convertase subtilisin/kexin type 4 Aliases ,DKFZp434B217,MGC34749,PC4,SPC5, Gene summary Proprotein convertases, including PCSK4, are calcium-dependent serine proteases related to bacterial subtilisins and to yeast kexin. These enzymes process precursor proteins to their active forms by selective cleavage of the polypeptide at sites following paired basic amino acids. In mammals, this family comprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM 600488), furin (FUR; MIM 136950), and PACE4 (MIM 167405). Substrates for these enzymes range from prohormones to precursors for growth factors to cell surface receptors and viral surface glycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied by OMIM] Location Chromosome: 19   Locus: 19p13.3 Gene position 1490407 - 1481427  Map Viewer Gene orientation minus Gene size 8981 bp Gene sequence >PCSK4:complement(1421427..1430407):Length=8981 CCCACTCGGCGGTTTGGCGGGAGGGAGGGGATTTGCGCAGGCCCCGCTCCCGCCCCGCCT CCATGCGGCCCGCCCCGATTGCGCTGTGGCTGCGCCTGGTCTTGGCCCTGGCCCTTGTCC GCCCCCGGGCTGTGGGGTGGGCCCCGGTCCGAGCCCCCATCTATGTCAGCAGCTGGGCCG TCCAGGTGTCCCAGGGTAACCGGGAGGTCGAGCGCCTGGCACGCAAATTCGGCTTCGTCA ACCTGGGGCCGGTGGGTGGGACCGGGATAGACGGGAAGTGGGGGCTTGGAGGGGACTGAA CAACCCTAGACCCCGACAAGGGGGAGGGAGCCCACAAGGTCTTCTAAATATCAAGAGTCC CAGCCCACCCCTGCCTCAGCCAAGCTCAGCTTCTGGGACTCCCAGAGAGCACCTGCTGGG GAAGGACAAAGAAGGGGGCTGTTACCGGCCCTCGGGGGCTTCAGCAGGGGAGCCGGGTCC CATCGGTGCGGCCGCTTCCCCACATCCCCAGATCTTCCCTGACGGGCAGTACTTTCACCT GCGGCACCGGGGCGTGGTCCAGCAGTCCCTGACCCCGCACTGGGGCCACCGCCTGCACCT GAAGAAAAACCCCAAGGTGAGCCTGGCCTGGAGGCCAACCCCCTGCCCGGGGTCTCAGCT GCCTCCTGGGGCCACCAGCCATCTTCTGTGGTTCTCGTGGTTGTTATGAACAGCTGTGTG CTTTCTGTGGCTCAGACCCGCCCGGGCCCCAAGTCTATACAGCAAGAGGAGGCAGGAAGA CCCAGATACGGAAATCATGGCGCCTGCCAGGGCCTGGTACACAGTGGGCACCTCTTGTCC TCCCCCTCCCTCCTCTGGGCCCCAGGGGCTCTGGTAAGGAGGGACAGACGGCGTGACTTC CCCACCGTCTAGGTCATGGGATGGAGGGAAGGGGATTTTACGACACCGTAATGGGTTCCA AAGAGTAGGAGGCTTGGCCCGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAG GCGGAGGCGGTCGGATCACAAGGTCAGGAAATCGAGACGAGATCCTAGCGAACACGGTGA AACCCTGTCTCTACTGAAAATACAAAAAAATTAGCCGGGCATGGTGGCAGGCGCCTGTAG TCCCAGCTATTCAGGAGGCTTAGGCAGGAGAATGGTGTGAACCCGGGAGGCGGAGCTTGC AGTGAGCCGAGATCGCGCCATTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCA AAAAAAAAAAAAAAAAAAGTAGGAGGCTTACAGTCACCCAGTGGCCCTCAGGACGCAGTG TCCAGGCGCTCAGAAAGGGGCCTGGGTCCCATCGGGCTGGGCCCTGTCTAGAAAATGCCT GGGATGTCAAGCTGAGGGGTTGGGATGGAGCCTGGGAAGCCCTCGGAGGCCAGGAAGTGC CTTGAACAGGACTGGACAGCTGCCTGCTTACAGCACCGGGAGGGAGAGCAGTGGCCAGTT CCTGATGTGGTTTGCAAGAGAGAAGCCAGGCCTGGCGTGGTGGTTCATGCCTGTAATCCC GGCACTTCGGGAGGCCAAGGCAGGCAGATCACTTAAGCTCAGGAGTTCGAGACCAGCCTG ATCAACATGGCGAAACCCCATCTCTACTAAATGTACAAAAATTAGCCGGGCATGGTGGTG TGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTAGGAGAATCGCTTGAACCCAGGAG GCAGAGGTTGCAGTGAGCCAAGATTGCGCCACTGCACCCCAGCCTGGGCGACAGAACAAG ACTCTGTCTCAAAAAAAGAAAAAAAATAAGGAAGTGATGCAGGAGAGAGATAGAAGGATC TAGAACAGGGATGGGGGAGAGAGTGGGGTGGGGACCCGGGGACCTGCAGTCACCCGCGGC AGCAACGACGCGTCTGTGGGCCCAAGGACAGGTGGTCCAAAAGCCTCGACCCCTTCCGAC TGCAGACAGAGCCCCAGGCACATGGGGACCCTGGAGAGCAACCCCCACAAACACAGGGTC CCAGGGCACGGGGCTGCCTCACTCCCTGAACCACGAGGGGCCCCAGGGGCGAGCAGGGGA CAGGCCTGATGCACCCTCTGCTCTGCAGGTGCAGTGGTTCCAGCAGCAGACGCTGCAGCG GCGGGTGAAACGCTCTGTCGTGGTGCCCACGGACCCCTGGTTCTCCAAGCAGTGGTACAT GGTGAGCAGGCAGCCAGGGTGGGTAGACGGGGACGGGGCCGCTGGCGCCCTCAACTCCAG GCCCTCACAGGGTCACAACCCCGCCTCCCCCTGCAGAACAGCGAGGCCCAACCAGACCTG AGCATCCTGCAGGCCTGGAGTCAGGGGCTGTCAGGCCAGGGCATCGTGGTCTCTGTGCTG GACGATGGCATCGAGAAGGACCACCCGGACCTCTGGGCCAACTACGTGAGACCGCGGGTG GCTGTGGGCGAGGGCTGCCCCAGGTGCCGAGGCTGGCACCACCCTAGGGACGCCTCCCGG CCCCCTCATATCCCCACCTGCCCCCAGGACCCCCTGGCCAGCTATGACTTCAATGACTAC GACCCGGACCCCCAGCCCCGCTACACCCCCAGCAAAGAGAACCGGTGAGCAGGGCTCCCA CAGCACACGGGGGAAGCCCCAGTACCCGGCAGGGGGATGGAGGCCGTGACAGGAGCCCCT CTTGGCCCTGGCACCAGGCACGGGACCCGCTGTGCTGGGGAGGTGGCCGCGATGGCCAAC AATGGCTTCTGTGGTGTGGGGGTCGCTTTCAACGCCCGAATCGGAGGTACCCGGGGTCCC CCAGCGGCACCATTCCGGGACAGAGAGGGAAGGGGGTGACTCTGGCGGGGAGCTGGGCCC AAGGACTCGGGAGCCCACCCTCTCACTGCTGGGTGGTGCTAGGGCCCCAGACTCCAGGGC TTGGGGGGTGCTGAGCCAATACGAATGGTCCCACTCCAGGGAGCAGAGAGAGGGCCCAGG TAGGGCTGGGGAGTGGTGTGGAGTGGCGCGGGGCGGGCTGGGGTGTGGGGAAGGGCAGGG CCGGTGGCAGCGGCCCTCCCGCCCTGGCTCTGCAGGCGTACGGATGCTGGACGGTACCAT CACCGATGTCATCGAGGCCCAGTCGCTGAGCCTGCAGCCGCAGCACATCCACATTTACAG CGCCAGCTGGGGTCCCGAGGACGACGGCCGCACGGTGGACGGCCCCGGCATCCTCACCCG CGAGGCCTTCCGGCGTGGTGTGACCAAGGTGAGTGGCAGCCCGAGGAGGGCAGGGGTGGC AGGCCAGGCCGACGCCCCCTCCCCGCCCCTCCTGGTTTCCCAGGGCCGCGGCGGGCTGGG CACGCTCTTCATCTGGGCCTCGGGCAACGGCGGCCTGCACTACGACAACTGCAACTGCGA CGGCTACACCAACAGCATCCACACGCTTTCCGTGGGCAGCACCACCCAGCAGGGCCGCGT GCCCTGGTACAGCGAAGCCTGCGCCTCCACCCTCACCACCACCTACAGCAGCGGCGTGGC CACCGACCCCCAGATCGTGAGTGCAGCCGCCCCAACAGGGTCCCCTCCCCAGGCCCTGCC ATCCCAGCCTGGCCTCCTCCTGTCCCCACCACTGTGACTTAGCACCCTCCCAAAGCTGCT TTGAAAATGCAAATCCAGGCCGAGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGG AGGCTAAGGCAGGCAGATCACAAGGTCAGGAGATCAAGACCATCCTGGCTAACATGGTGA AACCCTGTCTCTACTAAAACTACAAAAAAAAAAGGCCAGGCACGGTGGCTGACGCCTGTA ATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCGGGAGATCGAGACCATC CTGGCTAACAGAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGT GGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCATGAACCCG GGAGGCAGGGTTTGCAGTGAGCCGAGATCGGGCCACTGCACTCCAGCCTGGGCGACAGAG TGAGACTCCGTCTCAAAAATCAATCAATCAATCAATCAATAACCCAAATCCAGGCCAAGC ACAGTGGCTCGCGCCTGTAATCCCAGCACTTTGGGAGACCAAGGTGGGTGGATCACCTGA GGTCAAGAGTTCAGGACCAGCCTAGCCAACATGGCAAAACCCCATCTCTACTAAAAATAC AAAAAAAAATTAGCCAGGCATGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTG AGGCAGGAGAATCGCTTGAACCCCAGAGATGGAGGTTGCAGTGAGCCAAGATTGCACCAC TGCACTCCAGTTTAGGCCACAGAGCGAGACCCTGTCTCAAAACAAAACAAAACAAAACAA AACAAAAACAAATCCAGCCGGGCGCAACAGCTCACTTTGGGAGGCCAAAGTGGGAGAATC ACTTCAGCCCAGGGTTTCTTTTCATTTGTTTGTTTTTGAAGATGGAGTCTGGCTCTGTCG TCCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCA CACCATTCTCCTTCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCATGCC CGGCTAATTTTTTGTATTTTCAGTAGAGACAGGGTTTCACCATGTTAGCCAGGATGATCT CGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTG TGAGCCACAGTGCCCAGCACTTTCTTTTTTCTTTTGAGATGGAGTCTCGCTCTGTCACCC AGGCTGGGTGCAACAGAGTGAAGTGGCATGATCTCAGCTCACTGCAACCTACGCCTGCCG GGCTCAAGCGATTCTTGTGCCTCAGCCTCTTGAGCAGCTGAGACCACAAGCATGCCACCA TGTCCTGCTAATTTCTTTTGTATATTTTGTAGAGATGGCATTTCACCATGTTGGCCAGGC TGGTCTCCAACTCCTCAGGTCAAGCGATCCACCAGCCTCGGCCTCCCAAAGTGCCGGGAA TAGCAGGCCACGCCACCATGCCCGGCTAATTTTTTTGTATTTTCAGTAGAGACGGGGTTT CACCATGTTGGCCAGGCTCTTAGTTCTTTTTGAGCATAGTCCTTGTTACTTCTTGAACTC AGTCCTTGGAGTCCTTGGTACCTTTTTTTTTAAATTTTTTTGAGACAGAGTCTCACTCTG TCACCCAGGTTGGAGTGCAGTGGTGCAATCTTAGCTCACTGCAACCTCTACCTCCCAGGC TCAAGCGATCCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCACACTACCAC ACCCAGCTAATTCTTGTATTTTTCCTGTAGAGACGGGGTTTCACCATGTTGCCACAAGCT GGTCTCAAACTCCTGAGCTCAAACAATCTGCCCGCCTCAGCCTCCCAAAGTGTTGGGACT ACAGGCGTGAGCCACTGTGTGGCCAGTCCTTGGTACTTTTTGACTTCAGTTCTTGGTACT ATTTTTTTATTTTTTTGAGATGGAGTCTTGCCATGTTGCCCAGGCTGGAGTGCAACGGTG TGATCTTGGCTCACTGCAACCTCTGCCTCCTAGGTTCAAGTGATTGTCTTGCCTCAGCCT CCCAAGTAGCTGGGATTACAGGTGCCCCGCCACCATACCCGGGTAATTTTTTTGTATTTT TAGTAGAGACAAGGTGTTGACCAGGCTGGTCTCGAACTCCTGACCTCCGGTGATCCACCC ACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCACCCAGCCCTTGGTA CTTTTTGAATTCAGTCGTTAGTACTTTTTTTTTTTTAATCCAGAGTCTGGCTCTGTTGCC CAGGCTGGAGTGCAGTGGCGTGGGTGTGATCTCCGCTCACTGCAACCTCTGCCTGTCGGG TTCAAGTGATTCTCCTGTGTCAGCCTCCCGAGTAGCTGGAACTACAGGTGCCCGCCACCA TGCCTGGCTAATTTTTGTATTTTTGTAGAGTTGGGGTTTCACTATGTTGACCAGGCTGGT CTTGAACTCCTGACCTCAGACAACACGCCCGCCTCAGCCTCCCAAAGTGCTGGGATGACA GGCCTGAGCCACTGCGCCCGCCCAGTCCTTGGTACTTTTTGAAGAAGGGCTGTATTCTCA CTGTGCACGGCCCCCCGAGTCCCACCCCCCTCTGCCCTCAGGTCACCACGGACCTGCATC ACGGGTGCACAGACCAGCACACGGGCACCTCGGCCTCAGCCCCACTGGCGGCCGGCATGA TCGCCCTAGCGCTGGAGGCCAAGTAGGTGACTGCGGGGCCCGGTCCACCGCCCTCGCCCC CAGGCGCGGCCCGGCGGCTCACCCGCCCCCGCCCCCGCCCCCCGCAGCCCGTTCCTGACG TGGAGAGACATGCAGCACCTGGTGGTCCGCGCGTCCAAGCCGGCGCACCTGCAGGCCGAG GACTGGAGGACCAACGGCGTGGGGCGCCAAGGTGCGGCGGGGCCGGGCGGGGGCGGGGAC CCGGGGCCCACGGGGCGAGTGACTGCTGCCCTTCCGCGCAGTGAGCCATCACTACGGATA CGGGCTGCTGGACGCCGGGCTGCTGGTGGACACCGCCCGCACCTGGCTGCCCACCCAGCC GCAGAGGAAGTGCGCCGTCCGGGTCCAGAGCCGCCCCACGTGAGACCCCTGCGCGCCCCT CCGCTATCCCCGCTGGGGGTGTGGGGGACAGGCCTGAGGCCTCAGTTTACCCATCTGTAA AACGAGGGCTGGACCCCGTGACCTCTGAGCCCCGACCTCGCCTGCTGGCCGCCCACCCAC CCCCCAGCAGGCCGCAGGAGGGTCCTCACCCCTCGACCCCCTCAGCCCCATCCTGCCGCT GATCTACATCAGGGAAAACGTATCGGCCTGCGCCGGCCTCCACAACTCCATCCGCTCGCT GGAGCACGTGCAGGCGCAGCTGACGCTGTCCTACAGCCGGCGCGGAGACCTGGAGATCTC GCTCACCAGCCCCATGGGCACGCGCTCCACACTCGTGGCCATACGGTGAGCGGCCCGCAG AGGAGAGGGGGCGGCCTCATGCCCTGTCGGTAAACGCTGCCATCTACCCGGAGTGTCCTC ACGGGGAGGGGCCAGGCCCATAGGAGTCACACGGCAGCCTAGTTGGTGGGACCCCGAGTC ACACCCTCACCCACACCCAGAGGACACGCGGCCACCAGCGCGTGCGGTCAGACACTTCAT GGGGCTCTGCCGGCTTCACAAAGCCATCCCTCTTGACACCCCCACCCCCACCCACCCTTC TGTCCCAGACCCTTGGACGTCAGCACTGAAGGCTACAACAACTGGGTCTTCATGTCCACC CACTTCTGGGATGAGAACCCACAGGGCGTGTGGACCCTGGGCCTAGAGAACAAGGGCTAC TATTTCAACACGGGTGAGGGCGGGGCGGGGCTGTGGTGGGCGGGGCTTGGCTCTCCAACC TCCCCCCAGGGGCTCTGGAGCTAGCCTTGGTGACCGCACTGCAAAAGGGGTTCCCAGTGG CCTTCTCCAAGAGAACATGCACACAGTAGGCGTGCAGTCACCCGGGAGATGGTGTGCAAT GACAGGCACACAGTAGGTGTGCGGTAACACGGGAGATGTAGGTGCCCAGTGACAGGCGCA CAGTAGGTGTGCAGTCACCCGGGAGATGTCGGTGTCCAGTGACAGGCGCACAGTAGGTGT GCAATTCCCTGAGAGATGTGAACCAGTCCAGGGCCCCGCGTGGGAGCTGAAGGGGAGGGA GCCCGGGGACTACCAGGACCAGGCTGCCGAGAGCCTCCTTTTCCTCCTGTGCCCACCCGC GACCCCTGTCCAGGGACGTTGTACCGCTACACGCTGCTGCTCTATGGGACGGCCGAGGAC ATGACAGCGCGGCCTACAGGCCCCCAGGTGACCAGCAGCGCGTGTGTGCAGCGGGACACA GAGGGGCTGTGCCAGGGTGAGTGCCGGCGGGGCAGGGCCCACTGCTGGGAGGCGGTGGCG GCCACCGTGGGCAGCGTGCATGTGGCCCCAGGCGGGCGGGTGGCGAGTAACAGGCTGCGG GTGGCAAGCTGACGGGCCTTTGCGTGCGTGTCCCCGAGCAGCGTGTGACGGCCCCGCCTA CATCCTGGGACAGCTCTGCCTGGCCTACTGCCCCCCGCGGTTCTTCAACCACACAAGGCT GGTGACCGCTGGGCCTGGGCACACGGCGGCGCCCGCGCTGAGGGTCTGCTCCAGCTGCCA TGCCTCCTGCTACACCTGCCGCGGCGGCTCCCCGAGGGACTGCACCTCCTGTCCCCCATC CTCCACGCTGGACCAGCAGCAGGGCTCCTGCATGGGACCCACCACCCCCGACAGCCGCCC CCGGCTTAGAGCTGCCGCCTGTCCCCACCACCGCTGCCCAGCCTCGGCCATGGTGCTGAG CCTCCTGGCCGTGACCCTCGGAGGCCCCGTCCTCTGCGGCATGTCCATGGACCTCCCACT ATACGCCTGGCTCTCCCGTGCCAGGGCCACCCCCACCAAACCCCAGGTCTGGCTGCCAGC TGGAACCTGAAGTTGTCAGCTCAGAAAGCGACCTTGCCCCCGCCTGGGTCCCTGACAGGC ACTGCTGCCATGCTGCCTCCCCAGGCTGGCCCCAGAGGAGCGAGCACCAGCACCCGACGC CTGGCCTGCCAGGGATGGGCCCCGTGGAACCCCGAAGCCTGGCGGGAGAGAGAGAGAGAG AAGTCTCCTCTGCATTTTGGGTTTGGGCGGGAGTGGGCTGGGGGGAGAGGCTGGAGCACC CCAAAAGCCAGGGGAAAGTGGAGGGAGAGAAACGTGACACTGTCCGCCTCGGGCACCGCG TCCAACCTCAGAGTTTGCAAATAAAGGTTGCTTAGAAGGTG OMIM ID 600487