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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PPL (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5493
Official gene symbolPPL
Full nameperiplakin
Aliases,KIAA0568,MGC134872,
Gene summaryThe protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq]
LocationChromosome: 16   Locus: 16p13.3
Gene position4987136 - 4932508  Map Viewer
Gene orientationminus
Gene size54629 bp
Gene sequence
OMIM ID602871