Entrez gene ID | | 5493 |
Official gene symbol | | PPL |
Full name | | periplakin |
Aliases | | ,KIAA0568,MGC134872, |
Gene summary | | The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16p13.3 |
Gene position | | 4987136 - 4932508 Map Viewer |
Gene orientation | | minus |
Gene size | | 54629 bp |
Gene sequence |
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OMIM ID | | 602871 |
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