Entrez gene ID | | 5495 |
Official gene symbol | | PPM1B |
Full name | | protein phosphatase, Mg2+/Mn2+ dependent, 1B |
Aliases | | ,MGC21657,PP2C-beta-X,PP2CB,PP2CBETA,PPC2BETAX, |
Gene summary | | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2p21 |
Gene position | | 44396000 - 44461742 Map Viewer |
Gene orientation | | plus |
Gene size | | 65743 bp |
Gene sequence |
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OMIM ID | | 603770 |
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