Entrez gene ID | | 5519 |
Official gene symbol | | PPP2R1B |
Full name | | protein phosphatase 2, regulatory subunit A, beta |
Aliases | | ,MGC26454,PP2A-Abeta,PR65B, |
Gene summary | | This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q23.2 |
Gene position | | 111637169 - 111597632 Map Viewer |
Gene orientation | | minus |
Gene size | | 39538 bp |
Gene sequence |
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OMIM ID | | 603113 |