Entrez gene ID | | 5524 |
Official gene symbol | | PPP2R4 |
Full name | | protein phosphatase 2A activator, regulatory subunit 4 |
Aliases | | ,MGC2184,PP2A,PR53,PTPA, |
Gene summary | | Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q34 |
Gene position | | 131873228 - 131911225 Map Viewer |
Gene orientation | | plus |
Gene size | | 37998 bp |
Gene sequence |
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OMIM ID | | 600756 |
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