Entrez gene ID | | 55486 |
Official gene symbol | | PARL |
Full name | | presenilin associated, rhomboid-like |
Aliases | | ,PRO2207,PSARL,PSARL1,PSENIP2,RHBDS1, |
Gene summary | | This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3q27.1 |
Gene position | | 183602693 - 183547173 Map Viewer |
Gene orientation | | minus |
Gene size | | 55521 bp |
Gene sequence |
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OMIM ID | | 607858 |