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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for OTUD5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID55593
Official gene symbolOTUD5
Full nameOTU domain containing 5
Aliases,DKFZp761A052,DUBA,MGC104871,
Gene summaryThis gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
LocationChromosome: X   Locus: Xp11.23
Gene position48815648 - 48779301  Map Viewer
Gene orientationminus
Gene size36348 bp
Gene sequence
OMIM ID300713