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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRKAA2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5563
Official gene symbolPRKAA2
Full nameprotein kinase, AMP-activated, alpha 2 catalytic subunit
Aliases,AMPK,AMPK2,PRKAA,
Gene summaryThe protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p31
Gene position57110990 - 57181008  Map Viewer
Gene orientationplus
Gene size70019 bp
Gene sequence
OMIM ID600497