Entrez gene ID | | 5563 |
Official gene symbol | | PRKAA2 |
Full name | | protein kinase, AMP-activated, alpha 2 catalytic subunit |
Aliases | | ,AMPK,AMPK2,PRKAA, |
Gene summary | | The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p31 |
Gene position | | 57110990 - 57181008 Map Viewer |
Gene orientation | | plus |
Gene size | | 70019 bp |
Gene sequence |
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OMIM ID | | 600497 |
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