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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRKACB (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5567
Official gene symbolPRKACB
Full nameprotein kinase, cAMP-dependent, catalytic, beta
Aliases,DKFZp781I2452,MGC41879,MGC9320,PKACB,
Gene summarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Three alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.1
Gene position84543745 - 84704181  Map Viewer
Gene orientationplus
Gene size160437 bp
Gene sequence
OMIM ID176892