| Entrez gene ID | | 55690 |
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| Official gene symbol | | PACS1 |
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| Full name | | phosphofurin acidic cluster sorting protein 1 |
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| Aliases | | ,FLJ10209,KIAA1175, |
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| Gene summary | | This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq] |
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| Location | | Chromosome: 11 Locus: 11q13.1-q13.2 |
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| Gene position | | 65837824 - 66012213 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 174390 bp |
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| Gene sequence |
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| OMIM ID | | 607492 |
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