Entrez gene ID | | 55697 |
Official gene symbol | | VAC14 |
Full name | | Vac14 homolog (S. cerevisiae) |
Aliases | | ,ArPIKfyve,FLJ10305,FLJ36622,FLJ46582,MGC149815,MGC149816,TAX1BP2,TRX, |
Gene summary | | The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM] |
Location | | Chromosome: 16 Locus: 16q22.1-q22.2 |
Gene position | | 70835061 - 70721342 Map Viewer |
Gene orientation | | minus |
Gene size | | 113720 bp |
Gene sequence |
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OMIM ID | | 604632 |
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