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Gene information for PRKAR2A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5576
Official gene symbolPRKAR2A
Full nameprotein kinase, cAMP-dependent, regulatory, type II, alpha
Aliases,MGC3606,PKR2,PRKAR2,
Gene summarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq]
LocationChromosome: 3   Locus: 3p21.3-p21.2
Gene position48885270 - 48788093  Map Viewer
Gene orientationminus
Gene size97178 bp
Gene sequence
OMIM ID176910