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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRKAR2B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5577
Official gene symbolPRKAR2B
Full nameprotein kinase, cAMP-dependent, regulatory, type II, beta
Aliases,PRKAR2,RII-BETA,
Gene summarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q22
Gene position106685178 - 106802256  Map Viewer
Gene orientationplus
Gene size117079 bp
Gene sequence
OMIM ID176912