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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRKCE (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5581
Official gene symbolPRKCE
Full nameprotein kinase C, epsilon
Aliases,MGC125656,MGC125657,PKCE,nPKC-epsilon,
Gene summaryProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq]
LocationChromosome: 2   Locus: 2p21
Gene position45879043 - 46415129  Map Viewer
Gene orientationplus
Gene size536087 bp
Gene sequence
OMIM ID176975