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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRKCH (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5583
Official gene symbolPRKCH
Full nameprotein kinase C, eta
Aliases,MGC26269,MGC5363,PKC-L,PKCL,PRKCL,nPKC-eta,
Gene summaryProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq]
LocationChromosome: 14   Locus: 14q22-q23
Gene position61788515 - 62017698  Map Viewer
Gene orientationplus
Gene size229184 bp
Gene sequence
OMIM ID605437