Entrez gene ID | | 5585 |
Official gene symbol | | PKN1 |
Full name | | protein kinase N1 |
Aliases | | ,DBK,MGC46204,PAK1,PKN,PKN-ALPHA,PRK1,PRKCL1, |
Gene summary | | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19p13.1-p12 |
Gene position | | 14544166 - 14582679 Map Viewer |
Gene orientation | | plus |
Gene size | | 38514 bp |
Gene sequence |
| |
OMIM ID | | 601032 |
|