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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PSENEN (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 55851 Official gene symbol PSENEN Full name presenilin enhancer 2 homolog (C. elegans) Aliases ,MDS033,MSTP064,PEN-2,PEN2, Gene summary Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq] Location Chromosome: 19   Locus: 19q13.12 Gene position 36236494 - 36237903  Map Viewer Gene orientation plus Gene size 1410 bp Gene sequence >PSENEN:8504712..8506121:Length=1410 CTCGCCCAAAGAAGACTACAATCTCCAGGGAAACCTGGGGCGTCTCGCGCAAACGTCCAT AACTGAAAGTAGCTAAGGCACCCCAGCCGGAGGAAGTGAGCTCTCCTGGTGAGTTGGGGG TCGTTTCGCCCACCCTAGTAAATATAAAGAGCTCTTTAATCCAGCCAGCTTACTAGTGGG GGTGGGGATGCCCTGCTTTCAGCAAACCGACCTTTACATTTATCTCTGATTTGTTCTAAT AGGGGCGTGGTTGTTCGTGATCCTTGCATCTGTTACTTAGGGTCAAGGCTTGGGTCTTGC CCCGCAGACCCTTGGGACGACCCGGCCCCAGCGCAGCTATGAACCTGGAGCGAGTGTCCA ATGAGGAGAAATTGAACCTGTGCCGGAAGTACTACCTGGGTAAGGCAGATCGCTAGGGTC CCAGGAGAAGAGAGGGGACTGGACTAGAGCACCCGAGGGAAGAGGGCCTCGGGGCCTGGA TTCTTAAGTCTAAGAGATGAAGGACCTGCGAACGCCGACTCCTGGATTTGAGTGGGGAGG GCCTGGGTCCTGAGGAATGAGGAAGCTGGGGCCTCAATTTCTGGATCCCAAGAGAGGAGG GGGATTGAGGGCCTGGACTCTTGGGTCCTGTGAAAGAGATGGTTGAGGAATCAGATTCCT GGATCCCAAAGAGGAGCCAGATTCCTGAGTCCCTGACAACAGAAATCTCCATTTGAACTT GGGTGTGGGAGAGTTTCTTCCAAATAGATCTCGGTGGGAGTTGGAGAAGATCTTCATTGC CTTATGAGGTTTTGGGGTTTGTTTGTTTGTTTTTCTTTCTCCCTAGGGGGGTTTGCTTTC CTGCCTTTTCTCTGGTTGGTCAACATCTTCTGGTTCTTCCGAGAGGCCTTCCTTGTCCCA GCCTACACAGAACAGAGCCAAATCAAAGGCTGTGAGTCTAGAGCACAGAGGAGGGAGGCC AGTGGCAGGGGAGAGGGGGAAGCGGGGAATCTTGGTGGGAAGGGACAATGGAGGATCCAA AATGTTGGGGCTCTGGGTGAGAAGGGAAGGCTGGTCTAGGGAAGTCTGGAGAGCAGCCGG AGGCCAACCCTTCCAGCTTCTGTTTCCCATGACAGATGTCTGGCGCTCAGCTGTGGGCTT CCTCTTCTGGGTGATAGTGCTCACCTCCTGGATCACCATCTTCCAGATCTACCGGCCCCG CTGGGGTGCCCTTGGGGACTACCTCTCCTTCACCATACCCCTGGGCACCCCCTGACAACT TCTGCACATACTGGGGCCCTGCTTATTCTCCCAGGACAGGCTCCTTAAAGCAGAGGAGCC TGTCCTGGGAGCCCCTTCTCAAACTCCTAAGACTTGTTTTCATGTCCCACGTTCTCTGCT GACATCCCCCAATAAAGGACCCTAACTTTC OMIM ID 607632