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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRKCZ (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5590
Official gene symbolPRKCZ
Full nameprotein kinase C, zeta
Aliases,PKC-ZETA,PKC2,
Gene summaryProtein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.33-p36.2
Gene position1981909 - 2116834  Map Viewer
Gene orientationplus
Gene size134926 bp
Gene sequence
OMIM ID176982