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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAP2K3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5606
Official gene symbolMAP2K3
Full namemitogen-activated protein kinase kinase 3
Aliases,MAPKK3,MEK3,MKK3,PRKMK3,
Gene summaryThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q11.2
Gene position21187968 - 21218552  Map Viewer
Gene orientationplus
Gene size30585 bp
Gene sequence
OMIM ID602315