| Entrez gene ID | | 56137 |
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| Official gene symbol | | PCDHA12 |
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| Full name | | protocadherin alpha 12 |
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| Aliases | | ,MGC138485,MGC141932,PCDH-ALPHA12, |
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| Gene summary | | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq] |
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| Location | | Chromosome: 5 Locus: 5q31 |
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| Gene position | | 140254931 - 140391929 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 136999 bp |
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| Gene sequence |
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| OMIM ID | | 606318 |
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