Entrez gene ID | | 5624 |
Official gene symbol | | PROC |
Full name | | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | | ,APC,PC,PROC1, |
Gene summary | | This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. |
Location | | Chromosome: 2 Locus: 2q13-q14 |
Gene position | | 128175996 - 128186822 Map Viewer |
Gene orientation | | plus |
Gene size | | 10827 bp |
Gene sequence |
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OMIM ID | | 612283 |
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