| Entrez gene ID | | 5682 |
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| Official gene symbol | | PSMA1 |
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| Full name | | proteasome (prosome, macropain) subunit, alpha type, 1 |
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| Aliases | | ,HC2,MGC14542,MGC14575,MGC14751,MGC1667,MGC21459,MGC22853,MGC23915,NU,PROS30, |
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| Gene summary | | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
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| Location | | Chromosome: 11 Locus: 11p15.1 |
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| Gene position | | 14665180 - 14526422 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 138759 bp |
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| Gene sequence |
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| OMIM ID | | 602854 |
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