Entrez gene ID | | 5685 |
Official gene symbol | | PSMA4 |
Full name | | proteasome (prosome, macropain) subunit, alpha type, 4 |
Aliases | | ,HC9,HsT17706,MGC111191,MGC12467,MGC24813,PSC9, |
Gene summary | | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q25.1 |
Gene position | | 78832747 - 78841562 Map Viewer |
Gene orientation | | plus |
Gene size | | 8816 bp |
Gene sequence |
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OMIM ID | | 176846 |
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