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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SPPL2B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID56928
Official gene symbolSPPL2B
Full namesignal peptide peptidase-like 2B
Aliases,IMP4,KIAA1532,MGC111084,PSL1,
Gene summaryThis gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 19   Locus: 19p13.3
Gene position2328629 - 2355100  Map Viewer
Gene orientationplus
Gene size26472 bp
Gene sequence
OMIM ID608239