Entrez gene ID | | 5695 |
Official gene symbol | | PSMB7 |
Full name | | proteasome (prosome, macropain) subunit, beta type, 7 |
Aliases | | ,Z, |
Gene summary | | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit). [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q34.11-q34.12 |
Gene position | | 127177721 - 127115744 Map Viewer |
Gene orientation | | minus |
Gene size | | 61978 bp |
Gene sequence |
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OMIM ID | | 604030 |
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