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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PSMB7 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5695
Official gene symbolPSMB7
Full nameproteasome (prosome, macropain) subunit, beta type, 7
Aliases,Z,
Gene summaryThe proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit). [provided by RefSeq]
LocationChromosome: 9   Locus: 9q34.11-q34.12
Gene position127177721 - 127115744  Map Viewer
Gene orientationminus
Gene size61978 bp
Gene sequence
OMIM ID604030