| Entrez gene ID | | 5700 |
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| Official gene symbol | | PSMC1 |
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| Full name | | proteasome (prosome, macropain) 26S subunit, ATPase, 1 |
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| Aliases | | ,MGC24583,MGC8541,P26S4,S4,p56, |
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| Gene summary | | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq] |
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| Location | | Chromosome: 14 Locus: 14q32.11 |
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| Gene position | | 90722894 - 90738966 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 16073 bp |
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| Gene sequence |
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| OMIM ID | | 602706 |
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