| Entrez gene ID | | 5704 |
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| Official gene symbol | | PSMC4 |
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| Full name | | proteasome (prosome, macropain) 26S subunit, ATPase, 4 |
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| Aliases | | ,MGC13687,MGC23214,MGC8570,MIP224,S6,TBP7, |
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| Gene summary | | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq] |
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| Location | | Chromosome: 19 Locus: 19q13.11-q13.13 |
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| Gene position | | 40477073 - 40487353 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 10281 bp |
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| Gene sequence |
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| OMIM ID | | 602707 |
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